What is preimplantation genetic screening?

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Publication date: 11.02.2020

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Pre-implantation genetic screening has been developed to ensure the success of in vitro fertilization. The results of in vitro fertilization are influenced by a number of factors, such as: the age of the woman, the viability of the fetus, the number of embryos produced, and the quality of the embryos.

Using preimplantation genetic screening, a healthy embryo can be isolated from embryos obtained as a result of in vitro fertilization.

WHAT INFORMATION DOES PREIMPLANTATION GENETIC SCREENING PROVIDE?
Thanks to pre-implantation genetic screening, it is possible to study the chromosomes of each embryo, which allows you to select healthy embryos. According to chromosomal health, the embryo can be classified according to three criteria – euploid (healthy), aneuploid (presence of chromosomal abnormalities) and anmosaic (simultaneous presence of both normal and chromosomal abnormalities).

We offer preimplantation genetic screening using next generation sequencing technology, the most sophisticated embryo screening method that provides the most complete picture of chromosomal health.

Who benefits from preimplantation genetic screening?

Preimplantation genetic screening is acceptable for all IVF patients.

An embryo with a chromosomal pathology can form in the body of every woman. Regardless of the number of embryos produced, as a woman’s age increases, the risk of developing embryos with a chromosomal pathology also increases. Preimplantation genetic screening improves the chances of a successful pregnancy in women of all ages.

WHY ARE CHROMOSOMES IMPORTANT?
Chromosomes are structures that contain the genetic material necessary for human growth and development. Chromosomes, in each cell of a healthy person, there are 23 pairs or 46 chromosomes. A change in the number or structure of chromosomes leads to the birth of a fetus with a genetic disease, and also reduces the chances of a successful pregnancy.

HOW DOES PREIMPLANTATION GENETIC SCREENING IMPROVE OUTCOMES?
Preimplantation genetic screening has the following advantages:

The need for less time for the onset of pregnancy, which is associated with a decrease in the number of in vitro fertilization cycles.
The risk of spontaneous abortion is reduced, since the cause of abortion is mainly chromosomal pathologies.
The likelihood of embryo implantation and, therefore, a successful pregnancy increases.
Possibility of single embryo transfer and avoiding complications of unwanted multiple pregnancy.

IV-IV FERTILIZATION AND EMBRYO BIOPSY
5-7 days after in vitro fertilization, fertilization and incubation of embryos, placental cells are taken from the embryo. The embryo is not damaged during this process.

PREIMPLANTATION GENETIC SCREENING
A cell sample from each embryo is placed in a specialized tube, which is then analyzed in the laboratory using highly amplified next generation sequencing. During this time, the embryos are safely stored at the in vitro fertilization center.

RESEARCH ANSWER
After the examination, you will receive information about the chromosomal health of the embryos. thanks to which it is possible to select a healthy embryo, which, after being transferred to the uterus, has the highest chances of a successful conception.

Zhordania Clinic is one of the first leading specialized medical centers in the field of male and female reproductive medicine and gynecology.

Using international standards, the clinic diagnoses and treats problems associated with infertility, regardless of the causes of the difficulty.

The clinic has implemented internationally recognized standards of in vitro fertilization. The processes in the laboratory are managed in accordance with these standards. The laboratory is equipped with the latest technology and equipment in accordance with ESRHE recommendations.

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